MSANTD4

Across TCGA patient cohorts, MSANTD4 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MSANTD4-associated genes across cancer lineages are eIF4E, RBM15, and 14-3-3_beta. Each is linked with MSANTD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both MSANTD4-to-partner and partner-to-MSANTD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, eIF4E grouped by MSANTD4-low versus MSANTD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MSANTD4→partner) and Y-score (partner→MSANTD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	eIF4E →	+0.149	+1.736	.041	.007	3	2
UCEC	RBM15 →	+0.231	+2.000	.036	.009	3	2
UCEC	14-3-3_beta →	-0.075	-2.432	.031	.018	3	1
UCEC	EGFR_pY1068 →	-0.283	-2.459	.001	<.001	3	1
UCEC	A-Raf_pS299 →	-0.116	-2.700	.005	.005	3	1
UCEC	ERK2 →	+0.147	+1.736	.028	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

eIF4E by MSANTD4 expression — UCEC

Explore this box plot interactively →