MS4A8

Across TCGA patient cohorts, MS4A8 mutation is significantly associated with the RNA expression of many other genes, with 1,510 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A8-associated genes across cancer lineages are MRPL49, GDE1, and DLAT. Each is linked with MS4A8 in more than 2 cancer types. Because this analysis shows association rather than direction, both MS4A8-to-partner and partner-to-MS4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL49 grouped by MS4A8-low versus MS4A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A8→partner) and Y-score (partner→MS4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL49 →	+0.444	+2.601	.005	<.001	3	3
SKCM	GDE1 →	+0.635	+3.227	.002	.009	3	3
UCEC	DLAT →	+0.513	+1.925	.004	.005	3	2
UCEC	MRPL39 →	+0.420	+2.332	.001	<.001	3	2
UCEC	PANK4 →	+0.312	+2.512	.008	.009	3	2
UCEC	MRPS18C →	+0.388	+3.743	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,510 associations by consensus.

MRPL49 by MS4A8 expression — UCEC

Explore this box plot interactively →