MS4A8

Across TCGA patient cohorts, MS4A8 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A8-associated genes across cancer lineages are p62 Lck ligand, GSK3-a-b, and MEK1. Each is linked with MS4A8 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A8-to-partner and partner-to-MS4A8 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by MS4A8-low versus MS4A8-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A8→partner) and Y-score (partner→MS4A8) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.302	+2.331	.017	.019	3	2
UCEC	GSK3-a-b →	-0.162	-3.459	.002	.005	3	1
UCEC	MEK1 →	+0.388	+2.502	.006	.002	3	1
UCEC	MSH2 →	-0.343	-2.558	<.001	.010	3	1
UCEC	MSH6 →	-0.375	-2.000	.003	.029	3	1
UCEC	VHL →	-0.776	-1.807	.003	.025	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

p62 Lck ligand by MS4A8 expression — UCEC

Explore this box plot interactively →