MS4A6E

Across TCGA patient cohorts, MS4A6E mutation is significantly associated with the RNA expression of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A6E-associated genes across cancer lineages are TAB2-AS1, RN7SL474P, and SNRPGP17. Each is linked with MS4A6E in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A6E-to-partner and partner-to-MS4A6E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TAB2-AS1 grouped by MS4A6E-low versus MS4A6E-high in READ.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A6E→partner) and Y-score (partner→MS4A6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
READ	TAB2-AS1 →	+0.068	+4.925	<.001	.004	3	2
SKCM	RN7SL474P →	+0.061	+3.990	<.001	.009	3	2
UCEC	SNRPGP17 →	+0.346	+2.463	.001	.008	3	2
LIHC	RN7SL498P →	+0.278	+5.544	<.001	.004	3	2
UCEC	RN7SKP230 →	+0.340	+2.632	.006	.005	3	2
LIHC	OR11G2 →	+0.056	+5.878	.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

TAB2-AS1 by MS4A6E expression — READ

Explore this box plot interactively →