MS4A6E

Across TCGA cell cohorts, MS4A6E RNA expression is significantly associated with the mutation status of many other genes, with 116 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible MS4A6E-associated genes across cancer lineages are FXR1, ANKRD40, and MT-ND3. Each is linked with MS4A6E in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A6E-to-partner and partner-to-MS4A6E results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FXR1 grouped by MS4A6E-low versus MS4A6E-high in OESOPHAGUS.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A6E→partner) and Y-score (partner→MS4A6E) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	FXR1 →	+4.906	+0.050	.006	<.001	3	2
UPPER_AERODIGESTIVE_TRACT	ANKRD40 →	+4.357	+0.050	.006	<.001	3	2
LARGE_INTESTINE	MT-ND3 →	+4.437	+0.026	.004	<.001	3	2
LUNG_NSCLC_LUAD	MAP3K6 →	+5.228	+0.044	.005	<.001	3	2
LUNG_SCLC	MS4A12 →	+5.029	+0.072	.006	<.001	3	1
SOFT_TISSUE	TTLL4 →	+5.515	+0.317	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 116 associations by consensus.

FXR1 by MS4A6E expression — OESOPHAGUS

Explore this box plot interactively →