MS4A6A

Across TCGA pan-cancer cohorts, MS4A6A mass-spec protein differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of MS4A6A’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MS4A6A mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types MS4A6A is over-expressed in tumor, although a few such as COAD and LSCC show the opposite, repressed pattern.

CCRCC, COAD, and LSCC are the cancer types where MS4A6A tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MS4A6A mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	III,IV	+1.084	<.001	9	view →
COAD	All	All	−0.638	<.001	7	view →
LSCC	Male	II,III,IV	−0.350	<.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

MS4A6A–CCRCC

Open the CCRCC breakdown →