MS4A6A

Across TCGA pan-cancer cohorts, MS4A6A RNA is linked to patient survival in 20 of 34 cancer types, making it the most broadly survival-associated MS4A6A data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher MS4A6A RNA is associated with better overall survival. In most high-consensus cancer types, elevated MS4A6A expression acts as an unfavorable survival marker, although some lineages such as SKCM and HNSC show a favorable association.

SKCM, HNSC, and CESC are the cancer types where MS4A6A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	OS	Median	All	0.421	0.254	<.001	117	view →
HNSC	DFS	Tertile	III,IV	0.656	0.461	<.001	70	view →
CESC	DFS	Median	II,III,IV	0.873	0.675	.002	46	view →
LGG	OS	Median	All	0.372	0.533	<.001	41	view →
LUAD	DFS	Tertile	All	0.743	0.612	.002	36	view →
LAML	DFS	Quartile	All	0.338	0.815	<.001	30	view →
GBM	DFS	Quartile	All	0.189	0.470	.004	24	view →
UVM	DFS	Median	All	0.419	0.773	.014	22	view →
CHOL	DFS	Tertile	All	0.750	0.171	.005	18	view →
THYM	OS	Median	All	0.921	1.000	.011	14	view →
UCS	OS	Tertile	IV	0.665	0.255	.017	12	view →
THCA	DFS	Median	II,III,IV	0.952	0.777	.011	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 20 lineages.

MS4A6A–SKCM (OS)

Open the SKCM breakdown →