MS4A6A

Across TCGA patient cohorts, MS4A6A mutation is significantly associated with the RNA expression of many other genes, with 431 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A6A-associated genes across cancer lineages are MIR548U, RNA5SP138, and SNORD116-25. Each is linked with MS4A6A in more than 2 cancer types. Because this analysis shows association rather than direction, both MS4A6A-to-partner and partner-to-MS4A6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR548U grouped by MS4A6A-low versus MS4A6A-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A6A→partner) and Y-score (partner→MS4A6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MIR548U →	+0.123	+4.148	.003	.008	3	3
BLCA	RNA5SP138 →	+0.274	+7.640	<.001	.009	3	2
SKCM	SNORD116-25 →	+0.293	+3.869	<.001	<.001	3	2
SKCM	MIR5009 →	+0.229	+3.038	<.001	.004	3	2
LUAD	VN1R88P →	+0.598	+3.684	<.001	.004	3	2
LUSC	GYG2-AS1 →	+0.067	+3.301	<.001	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 431 associations by consensus.

MIR548U by MS4A6A expression — LUSC

Explore this box plot interactively →