MS4A6A

Across TCGA patient cohorts, MS4A6A mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A6A-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and JNK_pT183_Y185. Each is linked with MS4A6A in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A6A-to-partner and partner-to-MS4A6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MS4A6A-low versus MS4A6A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A6A→partner) and Y-score (partner→MS4A6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-2.973	.017	.035	3	1
UCEC	EGFR_pY1068 →	-0.330	-2.321	.006	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.172	-2.446	.034	.020	3	1
UCEC	MEK1 →	+0.401	+2.459	.023	.020	3	1
UCEC	Myosin-IIa →	+0.213	+2.818	.017	.035	3	1
UCEC	Paxillin →	+0.256	+2.820	.041	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

14-3-3_beta by MS4A6A expression — UCEC

Explore this box plot interactively →