MS4A6A

Across TCGA cell cohorts, MS4A6A mutation is significantly associated with the RNA expression of many other genes, with 713 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MS4A6A-associated genes across cancer lineages are IFNA4, RABGGTA, and CTSZ. Each is linked with MS4A6A in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A6A-to-partner and partner-to-MS4A6A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IFNA4 grouped by MS4A6A-low versus MS4A6A-high in CNS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A6A→partner) and Y-score (partner→MS4A6A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	IFNA4 →	+0.215	+5.321	<.001	.005	3	1
BLOOD_Leukemia	RABGGTA →	+0.391	+2.489	.002	.007	3	1
BLOOD_Leukemia	CTSZ →	+2.172	+3.228	.003	.004	3	1
BLOOD_Leukemia	RNF24 →	+1.049	+3.614	.003	<.001	3	1
BLOOD_Leukemia	SEL1L2 →	+0.477	+2.622	<.001	<.001	3	1
BLOOD_Leukemia	SIRPB1 →	+2.373	+3.115	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 713 associations by consensus.

IFNA4 by MS4A6A expression — CNS

Explore this box plot interactively →