MS4A5

Across TCGA patient cohorts, MS4A5 mutation is significantly associated with the RNA expression of many other genes, with 2,570 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A5-associated genes across cancer lineages are IGHD2-15, RAB5CP2, and OR2W4P. Each is linked with MS4A5 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A5-to-partner and partner-to-MS4A5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IGHD2-15 grouped by MS4A5-low versus MS4A5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A5→partner) and Y-score (partner→MS4A5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IGHD2-15 →	+1.097	+1.888	.008	.005	3	2
UCEC	RAB5CP2 →	+0.257	+2.573	<.001	<.001	3	2
SKCM	OR2W4P →	+0.049	+5.219	<.001	.002	3	2
LUSC	MIR3666 →	+0.442	+4.211	.007	.009	3	2
SKCM	ITIH4-AS1 →	+0.235	+3.720	.001	.006	3	1
SKCM	RN7SL591P →	+0.327	+5.097	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,570 associations by consensus.

IGHD2-15 by MS4A5 expression — UCEC

Explore this box plot interactively →