MS4A4A

Across TCGA pan-cancer cohorts, MS4A4A Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated MS4A4A data layer compared with 18 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher MS4A4A Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated MS4A4A expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, LIHC, and UCEC are the cancer types where MS4A4A Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	DFS	Median	II,III,IV	0.210	0.613	.011	12	view →
LIHC	DFS	Median	III,IV	0.040	0.361	<.001	6	view →
UCEC	DFS	Median	All	0.950	0.621	.029	2	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

MS4A4A–LUSC (DFS)

Open the LUSC breakdown →