MS4A4A

Across TCGA pan-cancer cohorts, MS4A4A RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MS4A4A’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MS4A4A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MS4A4A is over-expressed in tumor, although a few such as LUAD and COAD show the opposite, repressed pattern.

KIRC, LUAD, and COAD are the cancer types where MS4A4A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MS4A4A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.344	<.001	12	view →
LUAD	Female	II,III,IV	−1.230	<.001	9	view →
COAD	Female	All	−1.129	<.001	9	view →
LUSC	Male	II,III,IV	−2.048	<.001	8	view →
HNSC	Female	II,III,IV	+1.236	.001	7	view →
THCA	Male	IV	+1.140	.001	6	view →
BRCA	All	II,III,IV	−0.783	<.001	6	view →
KIRP	All	All	+1.247	<.001	3	view →
CHOL	All	II,III,IV	−1.739	.044	2	view →
PAAD	All	All	−1.717	.042	2	view →
UCEC	All	All	−0.703	.008	2	view →
READ	Female	All	−1.874	.019	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MS4A4A–KIRC

Open the KIRC breakdown →