MS4A4A

Across TCGA patient cohorts, MS4A4A RNA expression is significantly associated with the protein abundance of many other proteins, with 23,795 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible MS4A4A-associated proteins across cancer lineages are SKAP2, TBC1D2B, and VSIG4. Each is linked with MS4A4A in more than 9 cancer types. Because this analysis shows association rather than direction, both MS4A4A-to-partner and partner-to-MS4A4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MS4A4A versus SKAP2 in GBM, with a Pearson correlation of 0.84.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4A→partner) and Y-score (partner→MS4A4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SKAP2 →	+0.896	+1.653	<.001	<.001	3	10
GBM	TBC1D2B →	+0.432	+1.543	<.001	<.001	3	10
GBM	VSIG4 →	+1.221	+1.687	<.001	<.001	3	10
GBM	WAS →	+0.859	+1.800	<.001	<.001	3	10
OV	WIPF1 →	+0.477	+1.034	<.001	<.001	3	10
GBM	CD163 →	+1.264	+1.474	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 23,795 associations by consensus.

MS4A4A vs SKAP2 — GBM

Explore this scatter interactively →