MS4A4A

Across TCGA patient cohorts, MS4A4A protein abundance is significantly associated with the RNA expression of many other genes, with 383 significant associations in total. GBM shows the largest number of these associations.

The most reproducible MS4A4A-associated genes across cancer lineages are USP39, KLHL4, and C5. Each is linked with MS4A4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4A-to-partner and partner-to-MS4A4A results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, MS4A4A versus USP39 in COAD, with a Pearson correlation of 0.52.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4A→partner) and Y-score (partner→MS4A4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	USP39 →	+0.492	+0.418	.002	.004	3	2
COAD	KLHL4 →	-1.035	-0.467	<.001	.007	3	1
COAD	C5 →	+0.829	+0.428	.003	.003	3	1
COAD	MYH1 →	-0.060	-0.509	.006	.005	3	1
COAD	LYPLA2 →	+0.672	+0.652	.006	.007	3	1
COAD	OAS3 →	+2.020	+0.410	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 383 associations by consensus.

MS4A4A vs USP39 — COAD

Explore this scatter interactively →