MS4A4A

Across TCGA patient cohorts, MS4A4A mutation is significantly associated with the RNA expression of many other genes, with 912 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A4A-associated genes across cancer lineages are EZH2P1, RNU6-271P, and MTND3P20. Each is linked with MS4A4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4A-to-partner and partner-to-MS4A4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EZH2P1 grouped by MS4A4A-low versus MS4A4A-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4A→partner) and Y-score (partner→MS4A4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	EZH2P1 →	+0.122	+2.720	.001	.008	3	2
LUSC	RNU6-271P →	+0.113	+3.993	<.001	.009	3	2
LUSC	MTND3P20 →	+0.095	+4.321	<.001	.006	3	2
LUSC	NDUFA4P2 →	+0.292	+3.266	<.001	.002	3	2
LUSC	ATP6V1G1P1 →	+0.200	+2.947	<.001	.007	3	2
LUSC	MIR7849 →	+0.344	+2.982	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 912 associations by consensus.

EZH2P1 by MS4A4A expression — LUAD

Explore this box plot interactively →