MS4A4A

Across TCGA patient cohorts, MS4A4A mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A4A-associated genes across cancer lineages are FoxM1, INPP4B, and ACVRL1. Each is linked with MS4A4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4A-to-partner and partner-to-MS4A4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by MS4A4A-low versus MS4A4A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4A→partner) and Y-score (partner→MS4A4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.292	+2.999	.004	.035	3	1
UCEC	INPP4B →	-0.442	-2.222	<.001	.010	2	2
UCEC	ACVRL1 →	-0.132	-3.439	.015	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.208	-3.321	.002	.010	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.438	-2.459	.015	.019	3	1
UCEC	p62 Lck ligand →	+0.294	+2.415	.024	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

FoxM1 by MS4A4A expression — UCEC

Explore this box plot interactively →