MS4A4A

Across TCGA cell cohorts, MS4A4A mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible MS4A4A-associated genes across cancer lineages are DCSTAMP, PYDC1, and HES3. Each is linked with MS4A4A in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A4A-to-partner and partner-to-MS4A4A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DCSTAMP grouped by MS4A4A-low versus MS4A4A-high in URINARY_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A4A→partner) and Y-score (partner→MS4A4A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	DCSTAMP →	+0.039	+4.217	.008	.005	3	1
URINARY_TRACT	PYDC1 →	+0.105	+4.087	<.001	.009	3	1
URINARY_TRACT	HES3 →	+0.030	+4.087	<.001	.009	3	1
URINARY_TRACT	OR4N4 →	+0.022	+4.087	<.001	.009	3	1
URINARY_TRACT	GYPE →	+0.020	+4.217	.001	.005	3	1
URINARY_TRACT	USP17L8 →	+0.005	+4.087	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

DCSTAMP by MS4A4A expression — URINARY_TRACT

Explore this box plot interactively →