MS4A12

Across TCGA patient cohorts, MS4A12 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MS4A12-associated genes across cancer lineages are cIAP, JNK_pT183_Y185, and JNK2. Each is linked with MS4A12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MS4A12-to-partner and partner-to-MS4A12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by MS4A12-low versus MS4A12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MS4A12→partner) and Y-score (partner→MS4A12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.146	+2.196	.042	.034	3	2
UCEC	JNK_pT183_Y185 →	-0.234	-3.000	.008	.036	3	1
UCEC	JNK2 →	+0.272	+3.009	.008	.019	3	1
UCEC	Ku80 →	+0.311	+2.183	.012	.035	3	1
UCEC	p38-MAPK_pT180_Y182 →	-0.556	-3.000	.018	.036	3	1
UCEC	PDCD4 →	-0.708	-3.321	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

cIAP by MS4A12 expression — UCEC

Explore this box plot interactively →