MS4A12

Across TCGA pan-cancer cohorts, MS4A12 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of MS4A12’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where MS4A12 RNA is repressed in tumor relative to normal tissue. In most cancer types MS4A12 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and THCA are the cancer types where MS4A12 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MS4A12 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	IV	−5.940	<.001	11	view →
READ	Female	All	−7.068	<.001	5	view →
THCA	All	All	+0.278	<.001	3	view →
STAD	Male	III,IV	+0.175	.046	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

MS4A12–COAD

Open the COAD breakdown →