MRTFA-AS1

Across TCGA pan-cancer cohorts, MRTFA-AS1 RNA is linked to patient survival in 19 of 34 cancer types, making it the most broadly survival-associated MRTFA-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher MRTFA-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated MRTFA-AS1 expression acts as an unfavorable survival marker, although some lineages such as CESC and BLCA show a favorable association.

KIRC, ACC, and UCEC are the cancer types where MRTFA-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Median	All	0.518	0.728	<.001	168	view →
ACC	DFS	Quartile	II,III,IV	0.150	0.665	<.001	44	view →
UCEC	OS	Tertile	III,IV	0.767	0.873	.015	40	view →
CESC	OS	Tertile	IV	0.741	0.183	.002	24	view →
BLCA	OS	Quartile	II,III,IV	0.546	0.371	.009	23	view →
THCA	OS	Quartile	II,III,IV	0.709	0.978	.008	21	view →
LIHC	DFS	Quartile	All	0.163	0.324	.007	19	view →
LUAD	DFS	Median	III,IV	0.396	0.245	.023	15	view →
COAD	OS	Median	IV	0.720	0.345	.013	12	view →
SKCM	DFS	Median	IV	0.734	0.266	.003	12	view →
CHOL	DFS	Median	All	0.647	0.235	.016	9	view →
UVM	OS	Tertile	III,IV	0.571	0.959	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 19 lineages.

MRTFA-AS1–KIRC (DFS)

Open the KIRC breakdown →