MRTFA-AS1

Across TCGA pan-cancer cohorts, MRTFA-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of MRTFA-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MRTFA-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRTFA-AS1 is over-expressed in tumor, although a few such as LUAD and KICH show the opposite, repressed pattern.

HNSC, CHOL, and KIRC are the cancer types where MRTFA-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRTFA-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	+0.049	<.001	8	view →
CHOL	All	All	+0.151	<.001	5	view →
KIRC	Male	II,III,IV	+0.043	.010	4	view →
LUAD	All	III,IV	−0.120	.014	3	view →
KICH	All	All	−0.055	.005	3	view →
COAD	All	II,III,IV	+0.055	.010	3	view →
BRCA	All	III,IV	−0.153	<.001	2	view →
THCA	All	All	−0.047	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

MRTFA-AS1–HNSC

Open the HNSC breakdown →