MRRF

Across TCGA patient cohorts, MRRF mutation is significantly associated with the RNA expression of many other genes, with 67 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRRF-associated genes across cancer lineages are CCDC58P2, RN7SL837P, and RN7SL836P. Each is linked with MRRF in more than 1 cancer types. Because this analysis shows association rather than direction, both MRRF-to-partner and partner-to-MRRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CCDC58P2 grouped by MRRF-low versus MRRF-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRRF→partner) and Y-score (partner→MRRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	CCDC58P2 →	+0.060	+4.385	<.001	.008	3	1
SKCM	RN7SL837P →	+0.108	+5.408	<.001	.002	3	1
SKCM	RN7SL836P →	+0.215	+4.501	<.001	.002	3	1
SKCM	RN7SL598P →	+0.096	+6.225	<.001	<.001	3	1
UCEC	MIR548D2 →	+0.491	+3.694	<.001	.003	3	1
UCEC	MIR4725 →	+0.639	+3.709	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 67 associations by consensus.

CCDC58P2 by MRRF expression — SKCM

Explore this box plot interactively →