MRRF

Across TCGA pan-cancer cohorts, MRRF RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MRRF’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where MRRF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRRF is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.

LIHC, HNSC, and COAD are the cancer types where MRRF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRRF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.885	<.001	9	view →
HNSC	Male	IV	+0.709	<.001	8	view →
COAD	All	II,III,IV	+0.424	<.001	8	view →
LUSC	All	All	+0.411	<.001	8	view →
THCA	All	All	−0.244	<.001	8	view →
STAD	Male	II,III,IV	+0.817	<.001	7	view →
BLCA	Male	All	+0.520	.002	6	view →
KIRP	All	II,III,IV	+0.464	.010	6	view →
CHOL	All	All	+1.784	<.001	5	view →
READ	All	All	+0.527	.006	2	view →
PRAD	All	All	+0.365	<.001	2	view →
ESCA	All	All	+0.617	.035	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MRRF–LIHC

Open the LIHC breakdown →