MRRF

Across TCGA cell cohorts, MRRF RNA expression is significantly associated with the go_rna of many other GO terms, with 3,132 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRRF-associated GO terms across cancer lineages are Proteasome regulatory particle assembly, Positive regulation of mRNA 3'-end processing, and Mitochondrial RNA processing. Each is linked with MRRF in more than 13 cancer types. Because this analysis shows association rather than direction, both MRRF-to-partner and partner-to-MRRF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Proteasome regulatory particle assembly grouped by MRRF-low versus MRRF-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRRF→partner) and Y-score (partner→MRRF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Proteasome regulatory particle assembly →	+0.142	+0.698	.002	.003	3	14
KIDNEY	Positive regulation of mRNA 3'-end processing →	+0.120	+0.852	<.001	<.001	3	14
LUNG_SCLC	Mitochondrial RNA processing →	+0.081	+0.625	.008	<.001	3	10
LUNG_NSCLC_LUSC	Mitochondrial RNA 5'-end processing →	+0.144	+0.944	.003	.002	3	10
UPPER_AERODIGESTIVE_TRACT	snRNA metabolic process →	+0.055	+0.976	.008	.001	3	10
SOFT_TISSUE	Negative regulation of growth →	-0.051	-0.760	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,132 associations by consensus.

Proteasome regulatory particle assembly by MRRF expression — LIVER

Explore this box plot interactively →