MRPS7

Across TCGA patient cohorts, MRPS7 mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS7-associated genes across cancer lineages are 14-3-3_beta, EGFR, and ERK2. Each is linked with MRPS7 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS7-to-partner and partner-to-MRPS7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by MRPS7-low versus MRPS7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS7→partner) and Y-score (partner→MRPS7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.115	-2.301	.014	.034	3	1
UCEC	EGFR →	-0.185	-2.973	.013	.035	3	1
UCEC	ERK2 →	+0.177	+2.584	.049	.011	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.571	+3.331	.004	.005	3	1
UCEC	MSH2 →	-0.348	-2.973	.001	.035	3	1
UCEC	PRAS40_pT246 →	+0.236	+3.321	.003	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

14-3-3_beta by MRPS7 expression — UCEC

Explore this box plot interactively →