MRPS7

Across TCGA pan-cancer cohorts, MRPS7 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of MRPS7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where MRPS7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPS7 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and BLCA are the cancer types where MRPS7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.658	<.001	10	view →
LIHC	Male	All	+1.068	<.001	9	view →
BLCA	Male	All	+0.615	<.001	9	view →
THCA	All	All	−0.224	.001	9	view →
KICH	Female	II,III,IV	−1.661	<.001	8	view →
KIRP	All	II,III,IV	+0.383	.004	8	view →
LUSC	Male	II,III,IV	+0.662	<.001	6	view →
BRCA	All	III,IV	+0.563	<.001	6	view →
LUAD	All	All	+0.409	<.001	6	view →
COAD	Female	II,III,IV	+0.414	.009	4	view →
CHOL	Female	All	+1.563	<.001	3	view →
STAD	All	II,III,IV	+0.289	.011	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

MRPS7–HNSC

Open the HNSC breakdown →