MRPS6

Across TCGA patient cohorts, MRPS6 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. COAD shows the largest number of these associations.

The most reproducible MRPS6-associated genes across cancer lineages are CD8+ T-cells, CD8+ Tcm, and CD4+ memory T-cells. Each is linked with MRPS6 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS6-to-partner and partner-to-MRPS6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CD8+ T-cells grouped by MRPS6-low versus MRPS6-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS6→partner) and Y-score (partner→MRPS6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	CD8+ T-cells →	+0.059	+5.142	<.001	.041	3	1
COAD	CD8+ Tcm →	+0.101	+4.917	<.001	.048	3	1
COAD	CD4+ memory T-cells →	+0.039	+3.958	<.001	.035	3	1
COAD	CD4+ naive T-cells →	+0.031	+5.142	<.001	.041	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

CD8+ T-cells by MRPS6 expression — COAD

Explore this box plot interactively →