MRPS6

Across TCGA pan-cancer cohorts, MRPS6 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of MRPS6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where MRPS6 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPS6 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, KIRC, and KICH are the cancer types where MRPS6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	III,IV	−2.133	<.001	11	view →
KIRC	Female	All	−1.440	<.001	11	view →
KICH	Female	All	−1.957	<.001	8	view →
HNSC	Male	IV	+0.891	<.001	8	view →
LUAD	Male	All	+0.590	<.001	7	view →
ESCA	Male	All	+0.641	.015	4	view →
LUSC	All	All	+0.351	<.001	3	view →
CHOL	Male	All	+0.838	.014	2	view →
BLCA	Female	All	+0.569	.045	2	view →
PRAD	All	All	−0.465	<.001	2	view →
LUSC	Male	III,IV	−0.462	.024	2	view →
LIHC	All	All	+0.209	.027	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

MRPS6–KIRP

Open the KIRP breakdown →