MRPS33

Across TCGA pan-cancer cohorts, MRPS33 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of MRPS33’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where MRPS33 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types MRPS33 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where MRPS33 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS33 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	All	−0.980	<.001	12	view →
LUAD	Female	II,III,IV	+0.830	<.001	9	view →
LSCC	Male	All	+0.782	<.001	8	view →
COAD	Male	All	+0.427	<.001	8	view →
HNSC	Female	All	+0.302	.013	3	view →
OV	All	All	+0.964	<.001	2	view →
PDAC	All	II,III,IV	+0.440	.013	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

MRPS33–CCRCC

Open the CCRCC breakdown →