MRPS30-DT

Across TCGA pan-cancer cohorts, MRPS30-DT RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MRPS30-DT’s most consistent transcriptional readouts.

The strongest signal is observed in kidney chromophobe (KICH), where MRPS30-DT RNA is repressed in tumor relative to normal tissue. In most cancer types MRPS30-DT is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KICH, THCA, and HNSC are the cancer types where MRPS30-DT tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS30-DT RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KICH	Female	II,III,IV	−1.555	<.001	10	view →
THCA	Male	All	−0.914	<.001	10	view →
HNSC	All	III,IV	+0.421	<.001	10	view →
KIRC	Male	III,IV	−0.514	<.001	9	view →
UCEC	All	II,III,IV	−0.745	<.001	8	view →
BLCA	All	All	−0.681	<.001	8	view →
LIHC	Female	All	+0.318	<.001	8	view →
BRCA	All	III,IV	+1.558	.001	6	view →
COAD	All	All	−0.362	.001	5	view →
READ	All	All	−0.873	.019	4	view →
KIRP	Male	All	−0.510	<.001	4	view →
CHOL	All	All	+1.538	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MRPS30-DT–KICH

Open the KICH breakdown →