MRPS25

Across TCGA pan-cancer cohorts, MRPS25 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS25 data layer compared with 25 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS25 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPS25 expression acts as an unfavorable survival marker, although some lineages such as LSCC and PDAC show a favorable association.

LSCC, PDAC, and LUAD are the cancer types where MRPS25 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Quartile	II,III,IV	1.000	0.652	.009	14	view →
PDAC	DFS	Median	II,III,IV	0.515	0.309	.016	11	view →
LUAD	DFS	Quartile	III,IV	0.875	0.255	.013	6	view →
UCEC	DFS	Median	II,III,IV	0.509	0.867	.037	4	view →
HNSC	DFS	Median	IV	0.920	1.000	.028	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS25–LSCC (OS)

Open the LSCC breakdown →