MRPS25

Across TCGA pan-cancer cohorts, MRPS25 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of MRPS25’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where MRPS25 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPS25 is over-expressed in tumor, although a few such as KIRC and BRCA show the opposite, repressed pattern.

KIRC, LIHC, and THCA are the cancer types where MRPS25 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS25 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.935	<.001	11	view →
LIHC	Female	All	+0.722	<.001	9	view →
THCA	Male	All	+0.609	<.001	8	view →
STAD	All	II,III,IV	+0.493	<.001	8	view →
UCEC	All	II,III,IV	+0.618	.002	6	view →
COAD	All	II,III,IV	+0.264	<.001	6	view →
CHOL	All	All	+0.605	.001	4	view →
LUAD	All	III,IV	+0.416	.007	4	view →
READ	Female	All	+0.346	.002	4	view →
BRCA	Female	All	−0.209	.001	4	view →
HNSC	Female	All	−0.416	.011	3	view →
KICH	All	All	+0.341	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

MRPS25–KIRC

Open the KIRC breakdown →