MRPS25

Across TCGA patient cohorts, MRPS25 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS25-associated genes across cancer lineages are aDC, CD8+ naive T-cells, and CD8+ Tcm. Each is linked with MRPS25 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS25-to-partner and partner-to-MRPS25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, aDC grouped by MRPS25-low versus MRPS25-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS25→partner) and Y-score (partner→MRPS25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	aDC →	+0.094	+2.839	.027	.034	3	1
UCEC	CD8+ naive T-cells →	+0.053	+2.823	<.001	.036	3	1
UCEC	CD8+ Tcm →	+0.035	+2.935	.001	.013	3	1
UCEC	Macrophages M1 →	+0.021	+3.010	.015	.020	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

aDC by MRPS25 expression — UCEC

Explore this box plot interactively →