MRPS25

Across TCGA cell cohorts, MRPS25 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,396 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible MRPS25-associated GO terms across cancer lineages are Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA), Maturation of 5.8S rRNA, and Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Each is linked with MRPS25 in more than 16 cancer types. Because this analysis shows association rather than direction, both MRPS25-to-partner and partner-to-MRPS25 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) grouped by MRPS25-low versus MRPS25-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS25→partner) and Y-score (partner→MRPS25) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.102	+0.645	<.001	<.001	3	17
BONE	Maturation of 5.8S rRNA →	+0.116	+0.746	<.001	<.001	3	17
BONE	Cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.162	+0.798	.003	<.001	3	16
BONE	rRNA processing →	+0.112	+0.638	.002	.004	3	15
BONE	Endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) →	+0.121	+0.862	<.001	<.001	3	15
BONE	rRNA metabolic process →	+0.114	+0.805	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,396 associations by consensus.

Maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) by MRPS25 expression — BONE

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