MRPS22

Across TCGA patient cohorts, MRPS22 mutation is significantly associated with the RNA expression of many other genes, with 1,498 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS22-associated genes across cancer lineages are CICP6, MRPS36P3, and RPL23P4. Each is linked with MRPS22 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPS22-to-partner and partner-to-MRPS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CICP6 grouped by MRPS22-low versus MRPS22-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS22→partner) and Y-score (partner→MRPS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	CICP6 →	+0.018	+5.096	<.001	.008	3	3
BRCA	MRPS36P3 →	+0.307	+7.342	<.001	<.001	3	2
CESC	RPL23P4 →	+0.122	+4.653	.001	.004	3	2
UCEC	RNF19BPY →	+0.015	+3.738	<.001	.009	3	2
UCEC	RNA5SP413 →	+1.021	+1.746	<.001	.006	3	2
SKCM	CICP1 →	+0.019	+5.469	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,498 associations by consensus.

CICP6 by MRPS22 expression — BRCA

Explore this box plot interactively →