MRPS22

Across TCGA pan-cancer cohorts, MRPS22 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of MRPS22’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where MRPS22 RNA is repressed in tumor relative to normal tissue. In most cancer types MRPS22 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, LIHC, and HNSC are the cancer types where MRPS22 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS22 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	IV	−0.733	<.001	9	view →
LIHC	All	III,IV	+0.566	<.001	9	view →
HNSC	Male	III,IV	+0.606	<.001	8	view →
BLCA	Male	All	+0.503	<.001	7	view →
LUSC	All	All	+0.735	<.001	5	view →
STAD	All	II,III,IV	+0.327	.008	4	view →
BRCA	All	II,III,IV	+0.150	<.001	4	view →
ESCA	All	All	+0.536	.017	2	view →
KICH	All	All	−0.463	.005	2	view →
CHOL	All	All	+0.458	.007	2	view →
KIRC	Female	IV	+0.393	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

MRPS22–THCA

Open the THCA breakdown →