MRPS22

Across TCGA patient cohorts, MRPS22 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS22-associated genes across cancer lineages are FASN, PCNA, and 14-3-3_beta. Each is linked with MRPS22 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS22-to-partner and partner-to-MRPS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FASN grouped by MRPS22-low versus MRPS22-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS22→partner) and Y-score (partner→MRPS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FASN →	+0.389	+2.999	.020	.035	3	2
UCEC	PCNA →	+0.232	+2.459	.011	.019	3	2
UCEC	14-3-3_beta →	-0.120	-3.295	.005	.009	3	1
UCEC	A-Raf_pS299 →	-0.146	-3.584	.003	.002	3	1
UCEC	ERK2 →	+0.166	+2.999	.041	.035	3	1
UCEC	ACVRL1 →	-0.171	-3.446	.003	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

FASN by MRPS22 expression — UCEC

Explore this box plot interactively →