MRPS22

Across TCGA cell cohorts, MRPS22 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,836 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible MRPS22-associated GO terms across cancer lineages are Regulation of mitochondrial gene expression, Regulation of cap-independent translational initiation, and Positive regulation of cap-independent translational initiation. Each is linked with MRPS22 in more than 13 cancer types. Because this analysis shows association rather than direction, both MRPS22-to-partner and partner-to-MRPS22 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mitochondrial gene expression grouped by MRPS22-low versus MRPS22-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS22→partner) and Y-score (partner→MRPS22) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of mitochondrial gene expression →	+0.093	+0.647	.001	.004	3	14
BONE	Regulation of cap-independent translational initiation →	+0.164	+0.884	<.001	<.001	3	12
BONE	Positive regulation of cap-independent translational initiation →	+0.164	+0.884	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Protein localization to chromosome, centromeric region →	+0.122	+0.860	<.001	<.001	3	12
CNS	tRNA wobble base modification →	+0.065	+0.495	.001	<.001	3	12
OVARY	Chromosome localization →	+0.108	+0.846	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,836 associations by consensus.

Regulation of mitochondrial gene expression by MRPS22 expression — BONE

Explore this box plot interactively →