MRPS2

Across TCGA patient cohorts, MRPS2 mutation is significantly associated with the RNA expression of many other genes, with 895 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS2-associated genes across cancer lineages are RNU6-1213P, RN7SL91P, and RNU6-1258P. Each is linked with MRPS2 in more than 2 cancer types. Because this analysis shows association rather than direction, both MRPS2-to-partner and partner-to-MRPS2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1213P grouped by MRPS2-low versus MRPS2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS2→partner) and Y-score (partner→MRPS2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU6-1213P →	+0.263	+3.970	<.001	<.001	3	3
SKCM	RN7SL91P →	+0.295	+6.356	<.001	<.001	3	2
LUAD	RNU6-1258P →	+0.368	+7.930	<.001	.008	3	2
SKCM	RNU4-63P →	+0.293	+5.797	<.001	.001	3	2
BRCA	DUSP12P1 →	+0.255	+5.409	<.001	.005	3	1
UCEC	FERMT3 →	+0.667	+2.415	.003	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 895 associations by consensus.

RNU6-1213P by MRPS2 expression — UCEC

Explore this box plot interactively →