MRPS15

Across TCGA pan-cancer cohorts, MRPS15 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS15 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher MRPS15 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated MRPS15 expression acts as an unfavorable survival marker, although some lineages such as LSCC and LUAD show a favorable association.

LSCC, LUAD, and HNSC are the cancer types where MRPS15 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.949	0.437	<.001	36	view →
LUAD	DFS	Quartile	III,IV	0.875	0.255	.013	10	view →
HNSC	OS	Median	All	1.000	0.959	.023	5	view →
UCEC	OS	Tertile	All	1.000	0.926	.044	2	view →
CCRCC	DFS	Quartile	II,III,IV	1.000	0.816	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS15–LSCC (DFS)

Open the LSCC breakdown →