MRPS15

Across TCGA pan-cancer cohorts, MRPS15 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of MRPS15’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where MRPS15 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPS15 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, HNSC, and LIHC are the cancer types where MRPS15 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS15 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Female	All	+0.921	<.001	10	view →
HNSC	Male	III,IV	+0.490	<.001	10	view →
LIHC	Male	All	+0.879	<.001	9	view →
LUAD	Female	All	+0.460	<.001	8	view →
COAD	Female	II,III,IV	+0.672	<.001	7	view →
UCEC	All	III,IV	+1.188	<.001	6	view →
LUSC	Female	All	+0.622	<.001	6	view →
BRCA	All	III,IV	+0.379	<.001	6	view →
KICH	Female	All	−0.758	<.001	5	view →
STAD	All	II,III,IV	+0.530	<.001	4	view →
CHOL	All	All	+0.850	<.001	2	view →
ESCA	All	All	+0.554	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

MRPS15–BLCA

Open the BLCA breakdown →