MRPS12

Across TCGA patient cohorts, MRPS12 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS12-associated genes across cancer lineages are Ku80, p62 Lck ligand, and STAT3_pY705. Each is linked with MRPS12 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS12-to-partner and partner-to-MRPS12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by MRPS12-low versus MRPS12-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS12→partner) and Y-score (partner→MRPS12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.299	+3.179	.015	.010	3	1
UCEC	p62 Lck ligand →	+0.392	+2.179	.021	.034	3	1
UCEC	STAT3_pY705 →	-0.555	-3.321	<.001	.010	3	1
UCEC	Rad50 →	-0.373	-3.321	.003	.010	2	1
UCEC	MEK1 →	+0.556	+3.321	.003	.010	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

Ku80 by MRPS12 expression — UCEC

Explore this box plot interactively →