MRPS12

Across TCGA pan-cancer cohorts, MRPS12 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated MRPS12 data layer compared with 3 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher MRPS12 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated MRPS12 expression acts as an unfavorable survival marker, although some lineages such as SCLC and DLBC show a favorable association.

UVM, SKCM, and LUAD are the cancer types where MRPS12 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.373	0.744	<.001	105	view →
SKCM	OS	Median	All	0.263	0.407	<.001	70	view →
LUAD	OS	Tertile	All	0.266	0.434	.001	66	view →
LGG	DFS	Median	All	0.640	0.832	<.001	48	view →
ACC	DFS	Median	All	0.306	0.612	.001	47	view →
LIHC	OS	Tertile	All	0.424	0.722	<.001	45	view →
UCEC	OS	Median	All	0.831	0.913	.002	44	view →
KIRC	OS	Tertile	All	0.809	0.910	.002	36	view →
KIRP	OS	Median	All	0.896	0.965	.005	25	view →
LAML	DFS	Quartile	All	0.393	0.705	.001	24	view →
SCLC	OS	Tertile	II,III,IV	0.695	0.331	.002	19	view →
PAAD	OS	Median	II,III,IV	0.451	0.652	.015	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

MRPS12–UVM (OS)

Open the UVM breakdown →