MRPS11

Across TCGA patient cohorts, MRPS11 mutation is significantly associated with the RNA expression of many other genes, with 779 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS11-associated genes across cancer lineages are MIR6870, TAF9, and MIR8071-1. Each is linked with MRPS11 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS11-to-partner and partner-to-MRPS11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR6870 grouped by MRPS11-low versus MRPS11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS11→partner) and Y-score (partner→MRPS11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR6870 →	+0.562	+2.621	<.001	.002	3	1
UCEC	TAF9 →	+0.743	+3.606	<.001	.001	3	1
UCEC	MIR8071-1 →	+0.919	+1.951	.001	.009	3	1
UCEC	RN7SL248P →	+0.082	+3.606	<.001	.002	3	1
UCEC	ZNF280B →	+0.705	+3.191	<.001	.009	3	1
UCEC	PRAG1 →	+0.732	+2.818	.006	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 779 associations by consensus.

MIR6870 by MRPS11 expression — UCEC

Explore this box plot interactively →