MRPS10

Across TCGA pan-cancer cohorts, MRPS10 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated MRPS10 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher MRPS10 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated MRPS10 expression acts as an unfavorable survival marker, although some lineages such as PDAC and LSCC show a favorable association.

PDAC, LSCC, and HNSC are the cancer types where MRPS10 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Quartile	All	0.823	0.405	.001	25	view →
LSCC	DFS	Tertile	II,III,IV	0.956	0.591	.003	21	view →
HNSC	DFS	Median	IV	0.328	0.889	.014	12	view →
CCRCC	OS	Quartile	II,III,IV	1.000	0.699	.010	10	view →
LUAD	DFS	Median	III,IV	0.713	0.286	.026	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

MRPS10–PDAC (OS)

Open the PDAC breakdown →