MRPS10

Across TCGA pan-cancer cohorts, MRPS10 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of MRPS10’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where MRPS10 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types MRPS10 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

LUAD, THCA, and LIHC are the cancer types where MRPS10 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in MRPS10 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	II,III,IV	+0.979	<.001	11	view →
THCA	Male	III,IV	−0.688	<.001	10	view →
LIHC	Male	All	+0.942	<.001	9	view →
KICH	Female	II,III,IV	−1.621	<.001	8	view →
BRCA	All	III,IV	+0.401	<.001	8	view →
BLCA	All	All	+0.368	.002	7	view →
LUSC	Female	All	+0.881	<.001	6	view →
UCEC	All	II,III,IV	+0.599	.003	6	view →
KIRC	All	All	−0.187	.006	6	view →
CHOL	All	II,III,IV	+1.715	<.001	5	view →
COAD	All	II,III,IV	+0.423	.001	5	view →
STAD	All	All	+0.586	.002	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

MRPS10–LUAD

Open the LUAD breakdown →