MRPS10

Across TCGA patient cohorts, MRPS10 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPS10-associated genes across cancer lineages are ASNS, JNK2, and PDCD4. Each is linked with MRPS10 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPS10-to-partner and partner-to-MRPS10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by MRPS10-low versus MRPS10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPS10→partner) and Y-score (partner→MRPS10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.627	+3.169	<.001	.019	3	2
UCEC	JNK2 →	+0.316	+3.026	<.001	.018	3	1
UCEC	PDCD4 →	-0.551	-2.459	.015	.020	3	1
UCEC	STAT3_pY705 →	-0.334	-2.459	.008	.020	3	1
UCEC	ATM →	-0.488	-2.459	.026	.020	3	1
UCEC	Bax →	+0.228	+3.584	.049	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

ASNS by MRPS10 expression — UCEC

Explore this box plot interactively →