MRPL9

Across TCGA patient cohorts, MRPL9 mutation is significantly associated with the RNA expression of many other genes, with 557 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL9-associated genes across cancer lineages are RPS15AP27, MIR608, and MIR3646. Each is linked with MRPL9 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL9-to-partner and partner-to-MRPL9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RPS15AP27 grouped by MRPL9-low versus MRPL9-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL9→partner) and Y-score (partner→MRPL9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RPS15AP27 →	+0.169	+4.268	<.001	.008	3	2
UCEC	MIR608 →	+0.230	+3.036	.002	.009	3	2
BRCA	MIR3646 →	+0.269	+7.731	<.001	.009	3	1
HNSC	RNU4-37P →	+0.878	+7.954	<.001	.008	3	1
CESC	NFYAP1 →	+0.441	+5.010	<.001	.009	3	1
CESC	RPL31P59 →	+0.123	+5.010	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 557 associations by consensus.

RPS15AP27 by MRPL9 expression — SKCM

Explore this box plot interactively →