MRPL58

Across TCGA patient cohorts, MRPL58 mutation is significantly associated with the RNA expression of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible MRPL58-associated genes across cancer lineages are RNU4-58P, RNU4-16P, and RNU6-40P. Each is linked with MRPL58 in more than 1 cancer types. Because this analysis shows association rather than direction, both MRPL58-to-partner and partner-to-MRPL58 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-58P grouped by MRPL58-low versus MRPL58-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (MRPL58→partner) and Y-score (partner→MRPL58) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-58P →	+0.258	+3.133	.003	.009	3	1
UCEC	RNU4-16P →	+0.409	+3.316	<.001	.002	3	1
UCEC	RNU6-40P →	+0.524	+4.229	<.001	<.001	3	1
UCEC	RNU1-57P →	+0.307	+4.662	<.001	.003	3	1
UCEC	MIR199A2 →	+1.000	+2.963	<.001	.007	3	1
UCEC	IGLJ3 →	+2.388	+3.311	.002	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

RNU4-58P by MRPL58 expression — UCEC

Explore this box plot interactively →